Computational Modeling of Facial Response for Detecting Differential Traits in Autism Spectrum Disorders

This dissertation proposes novel computational modeling and computer vision methods for the analysis and discovery of differential traits in subjects with Autism Spectrum Disorders (ASD) using video and three-dimensional (3D) images of face and facial expressions. ASD is a neurodevelopmental disorder that impairs an individual’s nonverbal communication skills. This work studies ASD from the pathophysiology of facial expressions which may manifest atypical responses in the face. State-of-the-art psychophysical studies mostly employ na¨ıve human raters to visually score atypical facial responses of individuals with ASD, which may be subjective, tedious, and error prone. A few quantitative studies use intrusive sensors on the face of the subjects with ASD, which in turn, may inhibit or bias the natural facial responses of these subjects. This dissertation proposes non-intrusive computer vision methods to alleviate these limitations in the investigation for differential traits from the spontaneous facial responses of individuals with ASD. Two IRB-approved psychophysical studies are performed involving two groups of age-matched subjects: one for subjects diagnosed with ASD and the other for subjects who are typically-developing (TD). The facial responses of the subjects are computed from their facial images using the proposed computational models and then statistically analyzed to infer about the differential traits for the group with ASD. A novel computational model is proposed to represent the large volume of 3D facial data in a small pose-invariant Frenet frame-based feature space. The inherent pose-invariant property of the proposed features alleviates the need for an expensive 3D face registration in the pre-processing step. The proposed modeling framework is not only computationally efficient but also offers competitive performance in 3D face and facial expression recognition tasks when compared with that of the state-ofthe-art methods. This computational model is applied in the first experiment to quantify subtle facial muscle response from the geometry of 3D facial data. Results show a statistically significant asymmetry in specific pair of facial muscle activation (p\u3c0.05) for the group with ASD, which suggests the presence of a psychophysical trait (also known as an ’oddity’) in the facial expressions. For the first time in the ASD literature, the facial action coding system (FACS) is employed to classify the spontaneous facial responses based on facial action units (FAUs). Statistical analyses reveal significantly (p\u3c0.01) higher prevalence of smile expression (FAU 12) for the ASD group when compared with the TD group. The high prevalence of smile has co-occurred with significantly averted gaze (p\u3c0.05) in the group with ASD, which is indicative of an impaired reciprocal communication. The metric associated with incongruent facial and visual responses suggests a behavioral biomarker for ASD. The second experiment shows a higher prevalence of mouth frown (FAU 15) and significantly lower correlations between the activation of several FAU pairs (p\u3c0.05) in the group with ASD when compared with the TD group. The proposed computational modeling in this dissertation offers promising biomarkers, which may aid in early detection of subtle ASD-related traits, and thus enable an effective intervention strategy in the future

A Probabilistic Approach to Identifying Run Scoring Advantage in the Order of Playing Cricket

In the game of cricket, the result of coin toss is assumed to be one of the determinants of match outcome. The decision to bat first after winning the toss is often taken to make the best use of superior pitch conditions and set a big target for the opponent. However, the opponent may fail to show their natural batting performance in the second innings due to a number of factors, including deteriorated pitch conditions and excessive pressure of chasing a high target score. The advantage of batting first has been highlighted in the literature and expert opinions, however, the effect of batting and bowling order on match outcome has not been investigated well enough to recommend a solution to any potential bias. This study proposes a probability theory-based model to study venue-specific scoring and chasing characteristics of teams under different match outcomes. A total of 1117 one-day international matches held in ten popular venues are analyzed to show substantially high scoring advantage and likelihood when the winning team bat in the first innings. Results suggest that the same 'bat-first' winning team is very unlikely to score or chase such a high score if they were to bat in the second innings. Therefore, the coin toss decision may favor one team over the other. A Bayesian model is proposed to revise the target score for each venue such that the winning and scoring likelihood is equal regardless of the toss decision. The data and source codes have been shared publicly for future research in creating competitive match outcomes by eliminating the advantage of batting order in run scoring

Missing value estimation using clustering and deep learning within multiple imputation framework

Missing values in tabular data restrict the use and performance of machine learning, requiring the imputation of missing values. Arguably the most popular imputation algorithm is multiple imputation by chained equations (MICE), which estimates missing values from linear conditioning on observed values. This paper proposes methods to improve both the imputation accuracy of MICE and the classification accuracy of imputed data by replacing MICE’s linear regressors with ensemble learning and deep neural networks (DNN). The imputation accuracy is further improved by characterizing individual samples with cluster labels (CISCL) obtained from the training data. Our extensive analyses of six tabular data sets with up to 80% missing values and three missing types (missing completely at random, missing at random, missing not at random) reveal that ensemble or deep learning within MICE is superior to the baseline MICE (b-MICE), both of which are consistently outperformed by CISCL. Results show that CISCL + b-MICE outperforms b-MICE for all percentages and types of missing values. In most experimental cases, our proposed DNN-based MICE and gradient boosting MICE plus CISCL (GB-MICE-CISCL) outperform seven state-of-the-art imputation algorithms. The classification accuracy of GB-MICE-imputed data is further improved by our proposed GB-MICE-CISCL imputation method across all percentages of missing values. Results also reveal a shortcoming of the MICE framework at high percentages of missing values (50%) and when the missing type is not random. This paper provides a generalized approach to identifying the best imputation model for a tabular data set based on the percentage and type of missing values

Effect of Text Processing Steps on Twitter Sentiment Classification using Word Embedding

Processing of raw text is the crucial first step in text classification and sentiment analysis. However, text processing steps are often performed using off-the-shelf routines and pre-built word dictionaries without optimizing for domain, application, and context. This paper investigates the effect of seven text processing scenarios on a particular text domain (Twitter) and application (sentiment classification). Skip gram-based word embeddings are developed to include Twitter colloquial words, emojis, and hashtag keywords that are often removed for being unavailable in conventional literature corpora. Our experiments reveal negative effects on sentiment classification of two common text processing steps: 1) stop word removal and 2) averaging of word vectors to represent individual tweets. New effective steps for 1) including non-ASCII emoji characters, 2) measuring word importance from word embedding, 3) aggregating word vectors into a tweet embedding, and 4) developing linearly separable feature space have been proposed to optimize the sentiment classification pipeline. The best combination of text processing steps yields the highest average area under the curve (AUC) of 88.4 (+/-0.4) in classifying 14,640 tweets with three sentiment labels. Word selection from context-driven word embedding reveals that only the ten most important words in Tweets cumulatively yield over 98% of the maximum accuracy. Results demonstrate a means for data-driven selection of important words in tweet classification as opposed to using pre-built word dictionaries. The proposed tweet embedding is robust to and alleviates the need for several text processing steps.Comment: 14 pages, 3 figures, 7 table

Facial Landmark Feature Fusion in Transfer Learning of Child Facial Expressions

Automatic classification of child facial expressions is challenging due to the scarcity of image samples with annotations. Transfer learning of deep convolutional neural networks (CNNs), pretrained on adult facial expressions, can be effectively finetuned for child facial expression classification using limited facial images of children. Recent work inspired by facial age estimation and age-invariant face recognition proposes a fusion of facial landmark features with deep representation learning to augment facial expression classification performance. We hypothesize that deep transfer learning of child facial expressions may also benefit from fusing facial landmark features. Our proposed model architecture integrates two input branches: a CNN branch for image feature extraction and a fully connected branch for processing landmark-based features. The model-derived features of these two branches are concatenated into a latent feature vector for downstream expression classification. The architecture is trained on an adult facial expression classification task. Then, the trained model is finetuned to perform child facial expression classification. The combined feature fusion and transfer learning approach is compared against multiple models: training on adult expressions only (adult baseline), child expression only (child baseline), and transfer learning from adult to child data. We also evaluate the classification performance of feature fusion without transfer learning on model performance. Training on child data, we find that feature fusion improves the 10-fold cross validation mean accuracy from 80.32% to 83.72% with similar variance. Proposed fine-tuning with landmark feature fusion of child expressions yields the best mean accuracy of 85.14%, a more than 30% improvement over the adult baseline and nearly 5% improvement over the child baseline

Deep Adaptation of Adult-Child Facial Expressions by Fusing Landmark Features

Imaging of facial affects may be used to measure psychophysiological attributes of children through their adulthood, especially for monitoring lifelong conditions like Autism Spectrum Disorder. Deep convolutional neural networks have shown promising results in classifying facial expressions of adults. However, classifier models trained with adult benchmark data are unsuitable for learning child expressions due to discrepancies in psychophysical development. Similarly, models trained with child data perform poorly in adult expression classification. We propose domain adaptation to concurrently align distributions of adult and child expressions in a shared latent space to ensure robust classification of either domain. Furthermore, age variations in facial images are studied in age-invariant face recognition yet remain unleveraged in adult-child expression classification. We take inspiration from multiple fields and propose deep adaptive FACial Expressions fusing BEtaMix SElected Landmark Features (FACE-BE-SELF) for adult-child facial expression classification. For the first time in the literature, a mixture of Beta distributions is used to decompose and select facial features based on correlations with expression, domain, and identity factors. We evaluate FACE-BE-SELF on two pairs of adult-child data sets. Our proposed FACE-BE-SELF approach outperforms adult-child transfer learning and other baseline domain adaptation methods in aligning latent representations of adult and child expressions

Glioma Grading Using Structural Magnetic Resonance Imaging and Molecular Data

A glioma grading method using conventional structural magnetic resonance image (MRI) and molecular data from patients is proposed. The noninvasive grading of glioma tumors is obtained using multiple radiomic texture features including dynamic texture analysis, multifractal detrended fluctuation analysis, and multiresolution fractal Brownian motion in structural MRI. The proposed method is evaluated using two multicenter MRI datasets: (1) the brain tumor segmentation (BRATS-2017) challenge for high-grade versus low-grade (LG) and (2) the cancer imaging archive (TCIA) repository for glioblastoma (GBM) versus LG glioma grading. The grading performance using MRI is compared with that of digital pathology (DP) images in the cancer genome atlas (TCGA) data repository. The results show that the mean area under the receiver operating characteristic curve (AUC) is 0.88 for the BRATS dataset. The classification of tumor grades using MRI and DP images in TCIA/TCGA yields mean AUC of 0.90 and 0.93, respectively. This work further proposes and compares tumor grading performance using molecular alterations (IDH1/2 mutations) along with MRI and DP data, following the most recent World Health Organization grading criteria, respectively. The overall grading performance demonstrates the efficacy of the proposed noninvasive glioma grading approach using structural MRI

Information Mining for COVID-19 Research From a Large Volume of Scientific Literature

The year 2020 has seen an unprecedented COVID-19 pandemic due to the outbreak of a novel strain of coronavirus in 180 countries. In a desperate effort to discover new drugs and vaccines for COVID-19, many scientists are working around the clock. Their valuable time and effort may benefit from computer-based mining of a large volume of health science literature that is a treasure trove of information. In this paper, we have developed a graph-based model using abstracts of 10,683 scientific articles to find key information on three topics: transmission, drug types, and genome research related to coronavirus. A subgraph is built for each of the three topics to extract more topic-focused information. Within each subgraph, we use a betweenness centrality measurement to rank order the importance of keywords related to drugs, diseases, pathogens, hosts of pathogens, and biomolecules. The results reveal intriguing information about antiviral drugs (Chloroquine, Amantadine, Dexamethasone), pathogen-hosts (pigs, bats, macaque, cynomolgus), viral pathogens (zika, dengue, malaria, and several viruses in the coronaviridae virus family), and proteins and therapeutic mechanisms (oligonucleotide, interferon, glycoprotein) in connection with the core topic of coronavirus. The categorical summary of these keywords and topics may be a useful reference to expedite and recommend new and alternative directions for COVID-19 research

Survey on Deep Neural Networks in Speech and Vision Systems

This survey presents a review of state-of-the-art deep neural network architectures, algorithms, and systems in speech and vision applications. Recent advances in deep artificial neural network algorithms and architectures have spurred rapid innovation and development of intelligent speech and vision systems. With availability of vast amounts of sensor data and cloud computing for processing and training of deep neural networks, and with increased sophistication in mobile and embedded technology, the next-generation intelligent systems are poised to revolutionize personal and commercial computing. This survey begins by providing background and evolution of some of the most successful deep learning models for intelligent speech and vision systems to date. An overview of large-scale industrial research and development efforts is provided to emphasize future trends and prospects of intelligent speech and vision systems. Robust and efficient intelligent systems demand low-latency and high fidelity in resource-constrained hardware platforms such as mobile devices, robots, and automobiles. Therefore, this survey also provides a summary of key challenges and recent successes in running deep neural networks on hardware-restricted platforms, i.e. within limited memory, battery life, and processing capabilities. Finally, emerging applications of speech and vision across disciplines such as affective computing, intelligent transportation, and precision medicine are discussed. To our knowledge, this paper provides one of the most comprehensive surveys on the latest developments in intelligent speech and vision applications from the perspectives of both software and hardware systems. Many of these emerging technologies using deep neural networks show tremendous promise to revolutionize research and development for future speech and vision systems